L-GULONO-GAMMA-LACTONE OXIDASE IS THE ENZYME RESPONSIBLE FOR THE PRODUCTION OF METHYLGUANIDINE IN THE RAT-LIVER

被引：12

作者：

FUJITSUKA, N

YOKOZAWA, T

OURA, H

AKAO, T

KOBASHI, K

IENAGA, K

NAKAMURA, K

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, WAKAN YAKU RES INST, TOYAMA, TOYAMA 93001, JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV, FAC PHARMACEUT SCI, TOYAMA, TOYAMA 93001, JAPAN

[3] NIPPON ZOKI PHARMACEUT CO LTD, INST BIOACT SCI, HYOGO, JAPAN

来源：

NEPHRON | 1993年 / 63卷 / 04期

关键词：

L-GULONO-GAMMA-LACTONE OXIDASE; ASCORBIC ACID; METHYLGUANIDINE; CREATININE; CREATOL; RENAL FAILURE; RAT LIVER;

D O I：

10.1159/000187250

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A methylguanidine-synthesizing enzyme localized in rat liver microsomes produces methylguanidine via the intermediates creatone A and creatone B from the substrate, creatol, a substance produced from creatinine mainly by reaction with hydroxyl radicals. This enzyme has been indentified as L-gulono-gamma-lactone oxidase (EC 1.1.3.8). However, no corresponding activity was found in extracts from human livers.

引用

页码：445 / 451

页数：7

共 20 条

[1]

BARSOTTI G, 1975, KIDNEY INT S, V7, P299

[2] DIALYSIS OF METHYLGUANIDINE [J].