DESCRIPTION OF PULMONARY DEPOSITION OF RADIOLABELED AEROSOL BY AIRWAY GENERATION USING A CONCEPTUAL 3-DIMENSIONAL MODEL OF LUNG MORPHOLOGY

被引：66

作者：

FLEMING, JS ^{[1
]}

NASSIM, M ^{[1
]}

HASHISH, AH ^{[1
]}

BAILEY, AG ^{[1
]}

CONWAY, J ^{[1
]}

HOLGATE, S ^{[1
]}

HALSON, P ^{[1
]}

MOORE, E ^{[1
]}

MARTONEN, TB ^{[1
]}

机构：

[1] SOUTHAMPTON GEN HOSP,DEPT MED PHYS,SOUTHAMPTON SO16 6YD,HANTS,ENGLAND

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1995年 / 8卷 / 04期

关键词：

D O I：

10.1089/jam.1995.8.341

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Multi-modality medical imaging enables measurement of the three dimensional spatial distribution of a radiolabeled aerosol within the lung (Perring et al, 1994). A method is described for converting this information to distribution by airway generation number. The deposition data were first transformed to a hemispherical shape based on the fractional radial distance of each point in the lung from the centre of the lung to the corresponding extrapolated point on the periphery. A conceptual three dimensional hemispherical model of the spatial distribution of the airway network was then constructed based on the airway dimensions of the Weibel model (Weibel, 1991) and measurements of lung size and density distribution from computed tomography and magnetic resonance imaging. This then allowed description of the radiolabeled deposition data in the different airway generations. The principles of this process and an example of its application to the measured 3D distribution of radiolabeled aerosol in a human subject are described. The potential applications of the technique in the validation of the results of deposition modelling and in clinical aerosol inhalation therapy are discussed.

引用

页码：341 / 356

页数：16

共 21 条

[1]

AGNEW J., Characterising lung aerosol penetration, J. Aerosol Med., 4, pp. 237-249, (1991)

[2]

CONWAY J.H., HASHISH A., HALSON P., MOORE E., BAILEY A.G., NASSIM M., FLEMING J.S., HOLGATE S.T., The assessment of deposition of two types of nebulised aerosols in the lung via the use of single photon emission computed tomography and magnetic resonance imaging, Nucl. Med. Comm., 15, (1994)

[3]

FLEMING J.S., A technique for using CT images in attenuation correction and quantification in SPECT, Nucl. Med. Comm., 10, pp. 83-97, (1989)

[4]

FLEMING J.S., BRITTEN A.J., PERRING S., KEEN A.C., HOWLETT P.J., A general software system for the handling of medical images, J. Med. Eng. Tech., 15, pp. 162-169, (1991)

[5]

GERRITY T.R., LEE P.S., HAAS F.J., MARINELLI A., WERNER P., LOURENCO R.V., Calculated deposition of inhaled particles in the airway generations of normal subjects, J. Appl. Physiol., 47, pp. 867-873, (1979)

[6]

HALSON P.M., MOORE E., FLEMING J.S., CONWAY J., Quantitative analysis of pulmonary deposition by single photon emission computed tomography and magnetic resonance imaging, Brit. J. Radiol., 67, (1994)

[7]

HASHISH A.H., Influence of electrostatic charge on the deposition of therapeutic aerosols and airborne pollutants in the respiratory system., (1988)

[8]

HASHISH A.H., BAILEY A.G., WILLIAMS T.J., A mathematical model of the human lung which accounts for the depositional effect of charge on aerosol particles, Proc. 2nd conference of Aerosol Society., (1988)

[9]

HILL D.L.G., HAWKES D.J., CROSSMAN J.F., GLEESON M.J., COX T.C.S., BRACEY E. E. C.M. L., STRONG A.J., GRAVES P., Registration of MR and CT images for skull base surgery using point like anatomical features, Brit. J. Radiol., 64, pp. 1030-1035, (1991)

[10]

HORSFIELD K., GUMMING G., Morphology of the bronchial tree m man, J. App. Physiol., 24, 3, pp. 373-383, (1968)

← 1 2 3 →