MAPPING OF THE CONGENITAL GENERALIZED HYPERTRICHOSIS LOCUS TO CHROMOSOME XQ24-Q27.1

被引：47

作者：

FIGUERA, LE

PANDOLFO, M

DUNNE, PW

CANTU, JM

PATEL, PI

机构：

[1] BAYLOR COLL MED, DEPT NEUROL, HOUSTON, TX 77030 USA

[2] BAYLOR COLL MED, DEPT MOLEC & HUMAN GENET, HOUSTON, TX 77030 USA

[3] BAYLOR COLL MED, CTR HUMAN GENOME, HOUSTON, TX 77030 USA

[4] UNIV GUADALAJARA, CIBO IMSS, DIV GENET, GUADALAJARA 44430, JALISCO, MEXICO

[5] UNIV GUADALAJARA, CUCS, GUADALAJARA 44430, JALISCO, MEXICO

[6] IST NAZL NEUROL BESTA, DIV BIOCHEM & GENET, MILAN, ITALY

来源：

NATURE GENETICS | 1995年 / 10卷 / 02期

关键词：

D O I：

10.1038/ng0695-202

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Congenital generalized hypertrichosis (CGH) is a rare, fully penetrant X-linked dominant trait previously described in a single, multigenerational Mexican family. CGH is a visually striking phenotype characterized by excessive facial and upper torso hair in males and by less severe asymmetric hairiness in females. We have found significant evidence for linkage with several markers from the long arm of the X chromosome. Recombinant chromosomes place the CGH gene within a 22 cM interval between DXS425 and DXS1227 in Xq24-Xq27.1. The localization of a gene for CGH represents the first step towards the isolation of genes involved in hair growth pattern, particularly those involved in restriction of areas in humans.

引用

页码：202 / 207

页数：6

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