CHROMOSOMAL REARRANGEMENTS IN A PRIMARY HEPATOCELLULAR-CARCINOMA

被引：35

作者：

SIMON, D ^{[1
]}

MUNOZ, SJ ^{[1
]}

MADDREY, WC ^{[1
]}

KNOWLES, BB ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,DEPT MED,PHILADELPHIA,PA 19107

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 45卷 / 02期

关键词：

D O I：

10.1016/0165-4608(90)90091-N

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosome analysis of cells obtained at biopsy from a 65-year-old man with primary hepatocellular carcinoma revealed characteristic abnormalities of chromosomes 1, 5, 6, 9, 13, 16, and 22 in each cell and maintenance of a pseudodiploid chromosome number (46,XY). Five of the chromosomal sites involved in these rearrangements are either in fragile site regions or in regions containing genes that encode cellular oncogenes. Some of the tumor cells manifest mitotic deviations in the form of asynchronies, spiralization, premature centromere division, and non-sister chromatid associations. The significance of these findings to hepatocellular carcinogenesis is discussed. © 1990.

引用

页码：255 / 260

页数：6

共 20 条

[1]

BEASLEY RP, 1981, LANCET, V2, P1129

[2]

CAVANEE WK, 1983, NATURE, V305, P779

[3]

FARBER E, 1987, LAB INVEST, V56, P4

[4] LOSS OF HETEROZYGOSITY FOR THE SHORT ARM OF CHROMOSOME-1 IN HUMAN NEUROBLASTOMAS - CORRELATION WITH N-MYC AMPLIFICATION [J].