Superoxide dismutase mimetic activity of the metal (II) complexes of a dithiocarbamate derivative of beta-cyclodextrin

被引：28

作者：

Fragoso, Alex ^{[1
]}

Cao, Roberto ^{[1
]}

Villalonga, Reynaldo ^{[1
]}

机构：

[1] Univ Havana, Fac Chem, Lab Bioinorgan, Havana 10400, Cuba

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1995年 / 14卷 / 09期

关键词：

D O I：

10.1080/07328309508005418

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of a new beta-cyclodextrin derivative containing a dithiocarbamate group (3) by condensation of mono-2-methylamino-2-deoxy-beta-CD (2) with CS2 in the presence of NEt3 is reported. SOD-mimetic activity was found for the Mn(II) and Cu(II) complexes of 2 and 3 (IC50 = 0.76-7.4 mu M). To study the influence of the cyclodextrin residue on the catalytic activity of these complexes, a comparison was made with diethylamine and diethyldithiocarbamate complexes. Complexes of 2 and 3 resulted in 1.3 to 11 fold higher activities. An explanation for this observation, in terms of a possible cooperation of the cyclodextrin residue with the catalytic center of the complex, is given.

引用

页码：1379 / 1386

页数：8

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