THE EFFECT OF DIETARY ZINC-DEFICIENCY ON THE LIPID-COMPOSITION OF THE RAT ERYTHROCYTE-MEMBRANE

被引:30
作者
DRISCOLL, ER [1 ]
BETTGER, WJ [1 ]
机构
[1] UNIV GUELPH,COLL BIOL SCI,DEPT NUTR SCI,GUELPH N1G 2W1,ONTARIO,CANADA
关键词
D O I
10.1007/BF02536073
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of dietary zinc deficiency in the rat on the lipid composition of the erythrocyte membrane was determined. Weanling male Wistar rats were fed an egg white-based diet containing < 1.0 mg Zn/kg diet ad libitum. Control rats were either pair-fed or ad libitum-f ed the basal diet supplemented with 100 mg Zn/kg diet. A zinc refed group was fed the -Zn diet until day 18 and then pair-fed the +Zn diet until day 21. The voluntary feed restriction associated with dietary zinc deficiency resulted in erythrocyte membranes that had depressed phospholipid/ protein and elevated cholesterol/phospholipid ratios. Similarly, all feed restricted groups had elevated 22-carbon n-3 polyunsaturated fatty acids (PUFA) and depressed 22-carbon n-6 PUFA concentrations in alkenylacyl and diacyl glycerophosphoethanolamine, phosphatidylserine and phosphatidylcholine; they also had depressed 24:2n-6 levels in sphingomyelin. The relative concentrations of phospholipids in the membrane was similar between -Zn and +Zn (ad libitum) groups; however, the -Zn group had significantly less phosphatidylserine relative to +Zn (pair-fed) controls. Lipids 26, 459-466 (1991).
引用
收藏
页码:459 / 466
页数:8
相关论文
共 79 条