PHOTODYNAMIC MUTAGENICITY IN MAMMALIAN-CELLS

被引：19

作者：

GRUENER, N

LOCKWOOD, MP

机构：

[1] Tulane University School of Public Health, Tropical Medicine Department of Environmental Health Sciences New Orleans

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91257-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photoactivation of bound rose bengal in the presence of oxygen causes mutations in chinese hamster embryo cells. Visible light by itself can also cause a slight increase in mutation frequency. Both reactions are amplified by deuterium oxide. Singlet oxygen reactive compounds, β-carotene and 1,3-diphenylisobenzofuran diminish the toxic and mutagenic effects. 12-0-tetradecanoyl-phorbol-13-acetate, a potent tumor promoter, increases the number of mutants induced by the photodynamic action. The enhancement of mutagenesis by deuterium oxide and its reduction by specific singlet oxygen antagonists suggest that this active oxygen species is the direct mutagen. © 1979.

引用

页码：460 / 465

页数：6

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