MULTIPLE-MYELOMA COMPLICATED BY CONGESTIVE-HEART-FAILURE FOLLOWING 1ST ADMINISTRATION OF RECOMBINANT ALPHA-INTERFERON

被引：10

作者：

KOBAYASHI, T

SATO, Y

HASEGAWA, Y

NAGASAWA, T

YODA, Y

ABE, T

机构：

[1] Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba

来源：

INTERNAL MEDICINE | 1992年 / 31卷 / 07期

关键词：

ADVERSE REACTIONS; ABNORMAL ELECTROCARDIOGRAM;

D O I：

10.2169/internalmedicine.31.936

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 59-year-old female was admitted to Tsukuba University Hospital and diagnosed as IgA-lambda multiple myeloma (stage IIIA). No cardiovascular disorder with the exception of minor ischemic changes in ECG was revealed before treatment. Recombinant human alpha-interferon (IFN) at a dose of 3 million units combined with melphalan and prednisolone was administrated. Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF). Treatment with diuretics and catecholamine products showed almost complete recovery from CHF in 3 weeks. An adverse reaction to IFN was strongly suspected as the cause of CHF.

引用

页码：936 / 940

页数：5

共 27 条

[1]

Taylor J.L., Sabran J.L., Grossberg S.E., The cellular effects of interferon, Interferons and Their Applications, (1984)

[2]

Week P.K., Came P.E., Comparative biologic activities of human interferon, Interferons and Their Applications, (1984)

[3]

Trotta P.P., Preclinical biology of alpha interferons, Semin Oncol, 13, (1986)

[4]

Strander H., Interferon treatment of human neoplasia, Adv Cancer Res, 46, (1986)

[5]

Quesada J.R., Swanson D.A., Trindade A., Gutterman J.U., Renal cell carcinoma: Antitumor effects of leukocyte interferon, Cancer Res, 43, (1983)

[6]

Talpaz M., McCredie K.B., Mavligit G.M., Gutterman J.U., Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia, Blood, 62, (1983)

[7]

Ratain M.J., Vardiman J.W., Golomb H.M., The role of interferon in the treatment of hairy cell leukemia, Semin Oncol, 13, (1986)

[8]

Foon K.A., Roth M.S., Bunn P.A., Alpha interferon treatment of low-grade B-cell non-Hodgkin's lymphomas, cutaneous T-cell lymphomas and chronic lymphocytic leukemia, Semin Oncol, 13, (1986)

[9]

Cooper M.R., Welander C.E., Interferons in the treatment of multiple myeloma, Semin Oncol, 13, (1986)

[10]

Ohno R., Kodera Y., Ogura M., Et al., Treatment of plasma cell neoplasm with recombinant leukocyte A interferon and human lymphoblastoid interferon, Cancer Chemother Pharmacol, 14, (1985)

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