THE SYNTHESIS AND INVITRO ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF TACRINE (COGNEX(R)) DERIVATIVES

被引：68

作者：

GREGOR, VE

EMMERLING, MR

LEE, C

MOORE, CJ

机构：

[1] Parke-Davis Pharmaceutical Research, Warner-Lambert Co., Ann Arbor

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80545-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chlorosubstituted derivatives of tacrine (1), 1,4-methylenetacrine (2), and their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities are described. The most potent analogues are 6-chlorotacrine (1b) in AChE and 7-chlorotacrine (1c) in BChE inhibition.

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页码：861 / 864

页数：4

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