SEDATION WITH PROPOFOL DURING SURGERY UNDER LOCAL BLOCKADE - ASSESSMENT OF A TARGET-CONTROLLED INFUSION SYSTEM

被引：46

作者：

SKIPSEY, IG ^{[1
]}

COLVIN, JR ^{[1
]}

MACKENZIE, N ^{[1
]}

KENNY, GNC ^{[1
]}

机构：

[1] UNIV GLASGOW,GLASGOW ROYAL INFIRM,DEPT ANAESTHESIA,GLASGOW G31 2ER,SCOTLAND

来源：

ANAESTHESIA | 1993年 / 48卷 / 03期

关键词：

ANESTHETICS; INTRAVENOUS; PROPOFOL; ANESTHETIC TECHNIQUES; REGIONAL; SPINAL;

D O I：

10.1111/j.1365-2044.1993.tb06903.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The ability of a target‐controlled propofol infusion system to provide sedation for 40 patients undergoing surgery under regional blockade was assessed. Eighty‐eight per cent of the total infusion time was at the desired sedation level with little oversedation. This was achieved with a median blood propofol concentration of 0.93 μg.ml−1. The pharmacokinetic algorithm performed as well when used for sedation as for total intravenous anaesthesia. The predicted and measured blood propofol concentrations showed a bias of—12% and a precision of 34%. Copyright © 1993, Wiley Blackwell. All rights reserved

引用

页码：210 / 213

页数：4

共 19 条

[1] STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].

BLAND, JM ;

ALTMAN, DG .

LANCET, 1986, 1 (8476) :307-310

[2]

Dertwinkel R, 1988, Reg Anaesth, V11, P84

[3] SENSITIVITY TO PROPOFOL IN THE ELDERLY [J].

DUNDEE, JW ;

ROBINSON, FP ;

MCCOLLUM, JSC ;

PATTERSON, CC .

ANAESTHESIA, 1986, 41 (05) :482-485

[4] INHALATION SEDATION WITH 25-PERCENT NITROUS-OXIDE - REPORT OF A FIELD TRIAL [J].

EDMUNDS, DH ;

ROSEN, M .

ANAESTHESIA, 1984, 39 (02) :138-142

[5] PROPOFOL FOR LONG-TERM SEDATION IN THE INTENSIVE-CARE UNIT - A COMPARISON WITH PAPAVERETUM AND MIDAZOLAM [J].

HARRIS, CE ;

GROUNDS, RM ;

MURRAY, AM ;

LUMLEY, J ;

ROYSTON, D ;

MORGAN, M .

ANAESTHESIA, 1990, 45 (05) :366-372

[6] PHARMACOKINETIC IMPLICATIONS FOR THE CLINICAL USE OF PROPOFOL [J].

KANTO, J ;

GEPTS, E .

CLINICAL PHARMACOKINETICS, 1989, 17 (05) :308-326

[7] A PORTABLE COMPUTERIZED INFUSION SYSTEM FOR PROPOFOL [J].

KENNY, GNC ;

WHITE, M .

ANAESTHESIA, 1990, 45 (08) :692-693

[8]

KNELL PJW, 1985, POSTGRAD MED J, V61, P60

[9]

LARIJANI GE, 1990, DICP ANN PHARMAC, V24, P102

[10] CLINICAL-PHARMACOLOGY OF PROPOFOL - AN INTRAVENOUS ANESTHETIC AGENT [J].

LARIJANI, GE ;

GRATZ, I ;

AFSHAR, M ;

JACOBI, AG .

DICP-THE ANNALS OF PHARMACOTHERAPY, 1989, 23 (10) :743-749

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