PROTECTIVE EFFECTS OF CALCITONIN-GENE-RELATED PEPTIDE IN DIFFERENT EXPERIMENTAL-MODELS OF GASTRIC-ULCERS

被引：28

作者：

CLEMENTI, G

AMICOROXAS, M

CARUSO, A

CUTULI, VMC

MAUGERI, S

PRATO, A

机构：

[1] Institute of Pharmacology, University of Catania School of Medicine, Catania

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 238卷 / 01期

关键词：

CGRP (CALCITONIN GENE-RELATED PEPTIDE); GASTRIC ULCER; RESERPINE; SOMATOSTATIN;

D O I：

10.1016/0014-2999(93)90511-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intravenous administration of calcitonin gene-related peptide (CGRP) prevented in a dose-dependent manner reserpine-induced gastric mucosal damage, but failed to affect the lesions produced by ethanol administration. In pylorus-ligated rats, CGRP significantly reduced gastric volume, total acid and peptic activity output as well as ulcer formation. These protective effects of CGRP were not present when rats were pretreated with cysteamine. Our data suggest that CGRP exerts its antisecretory and antiulcer activity, at least in part, by interfering with somatostatin transmission.

引用

收藏

页码：101 / 104

页数：4

相关论文

共 12 条

[1] EFFECTS OF ALPHA-CALCITONIN AND BETA-CALCITONIN GENE-RELATED PEPTIDES UPON ION-TRANSPORT IN RAT DESCENDING COLON [J].

COX, HM ;

FERRAR, JA ;

CUTHBERT, AW .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (04) :996-998

[2] CALCITONIN GENE-RELATED PEPTIDE - A POTENT AND SELECTIVE STIMULATOR OF GASTROINTESTINAL SOMATOSTATIN SECRETION [J].

DUNNING, BE ;

TABORSKY, GJ .

ENDOCRINOLOGY, 1987, 120 (05) :1774-1781

[3] PROTECTION INDUCED BY CHOLECYSTOKININ-8 (CCK-8) IN ETHANOL-INDUCED GASTRIC-LESIONS IS MEDIATED VIA VAGAL CAPSAICIN-SENSITIVE FIBERS AND CCKA RECEPTORS [J].

EVANGELISTA, S ;

MAGGI, CA .

BRITISH JOURNAL OF PHARMACOLOGY, 1991, 102 (01) :119-122

[4]

EVANGELISTA S, 1988, INT J TISSUE REACT, V10, P253

[5] INFUSION OF A NOVEL PEPTIDE, CALCITONIN GENE-RELATED PEPTIDE (CGRP) IN MAN - PHARMACOKINETICS AND EFFECTS ON GASTRIC-ACID SECRETION AND ON GASTROINTESTINAL HORMONES [J].

KRAENZLIN, ME ;

CHNG, JLC ;

MULDERRY, PK ;

GHATEI, MA ;

BLOOM, SR .

REGULATORY PEPTIDES, 1985, 10 (2-3) :189-197

[6] THE INFLUENCE OF CIMETIDINE, A HISTAMINE-H2-RECEPTOR ANTAGONIST, ON THE GASTRIC EFFECTS OF RESERPINE IN RATS [J].

LAU, HK ;

OGLE, CW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1981, 70 (02) :139-148

[7] DISTRIBUTION AND CHROMATOGRAPHIC CHARACTERIZATION OF CGRP-LIKE IMMUNOREACTIVITY IN THE BRAIN AND GUT OF THE RAT [J].

MULDERRY, PK ;

GHATEI, MA ;

BISHOP, AE ;

ALLEN, YS ;

POLAK, JM ;

BLOOM, SR .

REGULATORY PEPTIDES, 1985, 12 (02) :133-143

[8] PRODUCTION OF A NOVEL NEUROPEPTIDE ENCODED BY THE CALCITONIN GENE VIA TISSUE-SPECIFIC RNA PROCESSING [J].

ROSENFELD, MG ;

MERMOD, JJ ;

AMARA, SG ;

SWANSON, LW ;

SAWCHENKO, PE ;

RIVIER, J ;

VALE, WW ;

EVANS, RM .

NATURE, 1983, 304 (5922) :129-135

[9] A QUANTITATIVE METHOD FOR MEASURING SPONTANEOUS GASTRIC SECRETION IN THE RAT [J].

SHAY, H ;

SUN, DCH ;

GRUENSTEIN, M .

GASTROENTEROLOGY, 1954, 26 (06) :906-913

[10]

SZABO S, 1980, REGUL PEPTIDES S1, V1, pS111