MORPHOLOGICAL OVERLAP BETWEEN CORTICOBASAL DEGENERATION AND PICKS-DISEASE - A CLINICOPATHOLOGICAL REPORT

被引：55

作者：

JENDROSKA, K

ROSSOR, MN

MATHIAS, CJ

DANIEL, SE

机构：

[1] PARKINSONS DIS SOC BRAIN BANK,LONDON WC1N 1PJ,ENGLAND

[2] INST NEUROL,LONDON WC1N 3BG,ENGLAND

[3] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,DEPT NEUROL,W-1000 BERLIN,GERMANY

[4] ST MARYS HOSP,SCH MED,DEPT NEUROL,LONDON,ENGLAND

[5] ST MARYS HOSP,SCH MED,LONDON,ENGLAND

[6] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,LONDON,ENGLAND

[7] NATL HOSP NEUROL & NEUROSURG,DEPT NEUROPATHOL,LONDON WC1N 3BG,ENGLAND

来源：

MOVEMENT DISORDERS | 1995年 / 10卷 / 01期

关键词：

CORTICOBASAL DEGENERATION; PICKS DISEASE; SWOLLEN NEURON; PICK BODY; BASOPHIL INCLUSION; NEUROFIBRILLARY TANGLE;

D O I：

10.1002/mds.870100118

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An 81-year-old woman died after a 3-year history of a progressive nondementing akinetic-rigid syndrome. Initially, there was a moderate response to levodopa treatment. Subsequently she developed postural tremor, loss of upward gaze, and frequent falls suggestive of Steele-Richardson-Olszewski syndrome (SROS). Macroscopical examination showed depigmentation of substantia nigra and locus ceruleus. Histology revealed occasional swollen achromatic neurons predominantly in frontal cortex, small cortical neurofibrillary tangles, brain stem basophil (corticobasal) inclusions, and Pick bodies. The coexistence of these histopathological markers raises questions concerning their specificity and the basis of a morphological distinction between corticobasal degeneration and Pick's disease.

引用

页码：111 / 114

页数：4

共 14 条

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