PHARMACOKINETICS OF CONTINUOUS RENAL REPLACEMENT THERAPY

The appropriate dosage adjustment of drugs during continuous extracorporeal renal replacement therapy requires an understanding of the clearance characteristics of the different techniques and knowledge of the pharmacokinetic parameters of the drugs. Extracorporeal drug removal can be calculated from these data. However, since pharmacokinetics are different in critically ill patients and in healthy volunteers, these calculations can only yield rough estimates and monitoring of drug level and/or clinical effect is still essential. © 1995 Springer-Verlag.