CROSS-RESISTANCE ANALYSIS FOR DU-6859A, A NEW FLUOROQUINOLONE, COMPARED TO 6 STRUCTURALLY SIMILAR COMPOUNDS (CIPROFLOXACIN, CLINAFLOXACIN, FLEROXACIN, LEVOFLOXACIN, OFLOXACIN, AND SPARFLOXACIN)

被引:11
作者
CORMICAN, MG
MARSHALL, SA
JONES, RN
机构
[1] Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA
关键词
D O I
10.1016/0732-8893(94)00116-E
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Emerging resistance to the current fluoroquinolones has encouraged synthesis of new compounds in this class. We have evaluated the activity of DU-6859a, a novel halogenated quinolone, against a panel of 300 bacteria, relative to the activity of ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin. DU-6859a was the most active of the fluoroquinolones studied and retains potentially useful activity against 80% of isolates resistant (minimum inhibitory concentration, greater than or equal to 4 mu g/ml) to ciprofloxacin. Continued clinical investigation of DU-6859a and similar new quinolones is urged.
引用
收藏
页码:51 / 54
页数:4
相关论文
共 23 条
[1]   MINIMUM INHIBITORY CONCENTRATION QUALITY-CONTROL GUIDELINES FOR BIAPENEM, DU-6859A, FK-037, LEVOFLOXACIN, GREPAFLOXACIN, AND CEFTIZOXIME WHEN USING VARIOUS NATIONAL COMMITTEE FOR CLINICAL LABORATORY STANDARDS SUSCEPTIBILITY TEST METHODS [J].
BALE, MJ ;
JONES, RN ;
ERWIN, ME ;
MURRAY, PR ;
WASHINGTON, JA ;
GERLACH, EH ;
THORNSBERRY, C ;
HINDLER, J ;
DOERN, GV .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1994, 19 (01) :65-68
[2]   RESISTANCE TO CIPROFLOXACIN APPEARING DURING THERAPY [J].
CHIN, NX ;
CLYNES, N ;
NEU, HC .
AMERICAN JOURNAL OF MEDICINE, 1989, 87 (5A) :S28-S31
[3]  
HOSHINO K, 1991, 31ST INT C ANT AG CH
[4]   POSTANTIBIOTIC EFFECT OF DU-6859A AND LEVOFLOXACIN AS COMPARED WITH OFLOXACIN [J].
HOUSTON, AK ;
JONES, RN .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1994, 18 (01) :57-59
[5]   THE IN-VITRO ACTIVITY OF A NEW HIGHLY-ACTIVE QUINOLONE, DU-6859A [J].
JOLLEY, A ;
ANDREWS, JM ;
BRENWALD, N ;
WISE, R .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 32 (05) :757-763
[6]   INTERPRETIVE CRITERIA FOR SUSCEPTIBILITY TESTS WITH DU-6859A AND FK-037 TESTED AGAINST HAEMOPHILUS-INFLUENZAE AND NEISSERIA-GONORRHOEAE [J].
JONES, RN ;
BARRETT, MS ;
BIEDENBACH, DJ .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1994, 19 (02) :93-99
[8]   INTERPRETIVE CRITERIA FOR CI-960 (AM-1091, PD127391) DISK DIFFUSION TESTS USING 5-MU-G DISKS [J].
JONES, RN ;
ERWIN, ME ;
BARRETT, MS .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1992, 15 (04) :379-381
[9]   INTERPRETIVE CRITERIA FOR DU-6859A DISK DIFFUSION TESTS USING 5-MU-G DISKS [J].
JONES, RN ;
JOHNSON, DM ;
ERWIN, ME .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1994, 18 (02) :125-127
[10]   INVITRO ACTIVITY OF AT-4140 AGAINST CLINICAL BACTERIAL ISOLATES [J].
KOJIMA, T ;
INOUE, M ;
MITSUHASHI, S .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (11) :1980-1988