CROSS-RESISTANCE ANALYSIS FOR DU-6859A, A NEW FLUOROQUINOLONE, COMPARED TO 6 STRUCTURALLY SIMILAR COMPOUNDS (CIPROFLOXACIN, CLINAFLOXACIN, FLEROXACIN, LEVOFLOXACIN, OFLOXACIN, AND SPARFLOXACIN)

被引：11

作者：

CORMICAN, MG

MARSHALL, SA

JONES, RN

机构：

[1] Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1995年 / 21卷 / 01期

关键词：

D O I：

10.1016/0732-8893(94)00116-E

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Emerging resistance to the current fluoroquinolones has encouraged synthesis of new compounds in this class. We have evaluated the activity of DU-6859a, a novel halogenated quinolone, against a panel of 300 bacteria, relative to the activity of ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin. DU-6859a was the most active of the fluoroquinolones studied and retains potentially useful activity against 80% of isolates resistant (minimum inhibitory concentration, greater than or equal to 4 mu g/ml) to ciprofloxacin. Continued clinical investigation of DU-6859a and similar new quinolones is urged.

引用

页码：51 / 54

页数：4

共 23 条

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