INHIBITORS OF DNA TOPOISOMERASE-I AND TOPISOMERASE-II ISOLATED FROM THE COPTIS RHIZOMES

被引：73

作者：

KOBAYASHI, Y ^{[1
]}

YAMASHITA, Y ^{[1
]}

FUJII, N ^{[1
]}

TAKABOSHI, K ^{[1
]}

KAWAKAMI, T ^{[1
]}

KAWAMURA, M ^{[1
]}

MIZUKAMI, T ^{[1
]}

NAKANO, H ^{[1
]}

机构：

[1] KYOWA HAKKO CO LTD,TOKYO RES LABS,MACHIDA,TOKYO 194,JAPAN

来源：

PLANTA MEDICA | 1995年 / 61卷 / 05期

关键词：

COPTIS CHINENSIS FRANCH; RANUNCULACEAE; TOPOISOMERASE I; TOPOISOMERASE II; PROTOBERBERINE; EPIBERBERINE; GROENLANDICINE; BERBERRUBINE;

D O I：

10.1055/s-2006-958127

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A water extract of Coptis chinensis was found to have the ability to stabilize the cleavable complex with mammalian DNA topoisomerase I. As the result of bioassay-guided fractionation, two protoberberine alkaloids, epiberberine and groenlandicine, were identified as active principles with topoisomerase I-mediated DNA cleavage activity in vitro. These two alkaloids did not induce topoisomerase II-mediated DNA cleavage. During further examination of the structurally related protoberberine alkaloids, berberrubine which is produced during the processing of Coptis rhizome as traditional medicine, was identified as a specific inducer of topoisomerase II-mediated DNA cleavage in vitro. These results indicated that protoberberine alkaloids are a chemical family which can induce cleavable complexes with topoisomerases I and II.

引用

页码：414 / 418

页数：5

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