SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF ETOPOSIDE A-RING ANALOGS

被引：8

作者：

KADOW, JF

TUN, MM

CROSSWELL, AR

ROSE, WC

VYAS, DM

DOYLE, TW

机构：

[1] Bristol-Myers Squibb Company, Wallingford, CT 06492

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80646-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The A ring of the clinical antitumor agent, etoposide, was opened to a protected 6,7-diphenol which was derivatized to form a number of new analogs. These compounds displayed activity inferior to etoposide when evaluated against several tumor cell lines in vitro and against murine P388 leukemia in vivo.

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页码：17 / 22

页数：6

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