NEW DIBENZOTHIADIAZEPINE DERIVATIVES WITH ANTIDEPRESSANT ACTIVITIES

被引：31

作者：

GIANNOTTI, D ^{[1
]}

VITI, G ^{[1
]}

SBRACI, P ^{[1
]}

PESTELLINI, V ^{[1
]}

VOLTERRA, G ^{[1
]}

BORSINI, F ^{[1
]}

LECCI, A ^{[1
]}

MELI, A ^{[1
]}

DAPPORTO, P ^{[1
]}

PAOLI, P ^{[1
]}

机构：

[1] UNIV FLORENCE,DIPARTIMENTO ENERGET,I-50139 FLORENCE,ITALY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 04期

关键词：

D O I：

10.1021/jm00108a018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 11-[(aminoalkyl)carbonyl] derivatives of 6,11-dihydrodibenzo[c,f][1,2,5]thiadiazepine 5,5-dioxide (10-39) were synthesized and evaluated for potential antidepressant activity in the apomorphine-induced hypothermia (Apo 16) test. Effects on reserpine-induced hypothermia and toxicity for the most potent antagonists of Apo 16 hypothermia were also studied. Structure-activity relationships are reported. Anticholinergic effects were evaluated for compound 12, identified as the most potent and least toxic in this series, by assessing physostigmine lethality. Compound 12 was also subjected to X-ray analysis.

引用

页码：1356 / 1362

页数：7

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