MODE OF INTERACTION OF 5-FLUOROURACIL, RADIATION, AND MITOMYCIN-C - INVITRO STUDIES

被引：11

作者：

DOBROWSKY, W ^{[1
]}

DOBROWSKY, E ^{[1
]}

RAUTH, AM ^{[1
]}

机构：

[1] ONTARIO CANC INST, DIV EXPTL THERAPEUT, TORONTO M4X 1K9, ONTARIO, CANADA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1992年 / 22卷 / 05期

关键词：

RADIATION; 5-FLUOROURACIL; MITOMYCIN-C; INVITRO; SCC-VIITO CELLS; DRUG RADIATION; INTERACTIONS;

D O I：

10.1016/0360-3016(92)90782-D

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An examination of the effects of radiation combined with either 5-fluorouracil, Mitomycin C, or both drugs in vitro has been made using a mouse squamous tumor cell line SCC VII(To) and cell viability as an endpoint. Depending on how the survival endpoint was calculated, the interaction of 5-fluorouracil, Mitomycin C, or 5-fluorouracil plus Mitomycin C with radiation was greater than additive (plating efficiency) or only additive (viable cells per flask). These results suggest that the cytostatic effect of these drugs may be an important aspect of their action clinically.

引用

页码：875 / 880

页数：6

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