OXYGEN-TRANSFER REACTIONS BY SYNTHETIC ANALOGS OF IRON-BLEOMYCIN

被引：10

作者：

DAWSON, DY ^{[1
]}

HUDSON, SE ^{[1
]}

MASCHARAK, PK ^{[1
]}

机构：

[1] UNIV CALIF SANTA CRUZ,DEPT CHEM & BIOCHEM,SANTA CRUZ,CA 95064

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1992年 / 47卷 / 02期

关键词：

D O I：

10.1016/0162-0134(92)84047-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic analogues of the iron-bleomycins, namely [Fe(PMA)]2+ and [Fe(PMA)]+, have been studied as oxotransfer agents. Oxygen transfer has been observed using iodosobenzene (PhIO), hydrogen peroxide, and dioxygen as oxygen sources. The primary substrates were cis- and trans-stilbene. The products were determined to be cis- and trans-stilbene oxide, benzaldehyde, and deoxybenzoin. These products were recovered in ratios similar to those reported for the iron-bleomycins, albeit in lower yields. Iron complexes of simpler analogues are inactive as oxotransfer agents. This study provides further support that PMAH is an accurate model of the metal binding region of bleomycin.

引用

页码：109 / 117

页数：9

共 37 条

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