INTERLEUKIN-6 DOES NOT ACTIVATE PROTEIN BREAKDOWN IN RAT SKELETAL-MUSCLE

被引：40

作者：

GARCIAMARTINEZ, C ^{[1
]}

LOPEZSORIANO, FJ ^{[1
]}

ARGILES, JM ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC BIOL,DEPT BIOQUIM & FISIOL,UNITAT BIOQUIM B,E-08071 BARCELONA,SPAIN

来源：

CANCER LETTERS | 1994年 / 76卷 / 01期

关键词：

INTERLEUKIN-6; PROTEIN; SKELETAL MUSCLE; TYROSINE;

D O I：

10.1016/0304-3835(94)90126-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein synthesis or that of alpha-(methyl)aminoisobutyric acid (MeAIB) uptake by the muscle preparations. It is concluded that IL-6 is not the mediator in activating muscle protein turnover during sepsis in the rat.

引用

页码：1 / 4

页数：4

共 19 条

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