RATIONAL DESIGN FOR CYTOSOLIC DELIVERY OF NUCLEOSIDE MONOPHOSPHATES - SATE AND DTE AS ENZYME-LABILE TRANSIENT PHOSPHATE PROTECTING GROUPS

被引：111

作者：

PERIGAUD, C ^{[1
]}

GOSSELIN, G ^{[1
]}

LEFEBVRE, I ^{[1
]}

GIRARDET, JL ^{[1
]}

BENZARIA, S ^{[1
]}

BARBER, I ^{[1
]}

IMBACH, JL ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2, CHIM BIOORGAN LAB,CNRS,URA 488,CASE COURRIER 008, PL EUGENE BATAILLON, F-34095 MONTPELLIER 5, FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80709-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

It was demonstrated that the use of neutral 2',3'-dideoxyuridine phosphotriesters which incorporate enzyme mediated bioreversible protection such as S-acetylthioethanol (SATE) or dithiodiethanol (DTE) resulted in intracellular delivery of the parent mononucleotide. This point was corroborated by observation of an anti-HIV effect in various cell lines and decomposition data in cell extracts.

引用

页码：2521 / 2526

页数：6

共 36 条

[1] NUCLEOTIDE DIMERS SUPPRESS HIV EXPRESSION INVITRO [J].