SUPPRESSION OF HYDROGEN PEROXIDE-INDUCED CYTOTOXICITY TOWARD CHINESE-HAMSTER LUNG FIBROBLASTS BY DECYLUBIQUINONE, A COENZYME-Q HOMOLOG

被引：4

作者：

NAKAYAMA, T ^{[1
]}

OGISO, Y ^{[1
]}

OSAWA, T ^{[1
]}

KAWAKISHI, S ^{[1
]}

机构：

[1] NAGOYA UNIV, DEPT APPL BIOL SCI, NAGOYA 46401, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 09期

关键词：

D O I：

10.1271/bbb.58.1702

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytotoxicity of hydrogen peroxide (H2O2) toward Chinese hamster V79 cells was assessed with a colony-formation assay. Decylubiquinone, a coenzy me Q homolog, suppressed H2O2-induced cytotoxicity. Almost all the incorporated decylubiquinone was detected as decylubiquinol after incubating the cells for 4h. These results suggest that decylubiquinol reduced in the cells acted as an antioxidant against H2O2-induced oxidative cell injury.

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页码：1702 / 1704

页数：3

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