PREPARATION OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE ESTERS AS POTENTIAL PRODRUGS

被引：7

作者：

ALEXANDER, P

HOLY, A

MASOJIDKOVA, M

机构：

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1994年 / 59卷 / 08期

关键词：

D O I：

10.1135/cccc19941853

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Esters of 9-(2-phosphonomethoxyethyl)adenine with substituted aliphatic alcohols were prepared as potential prodrugs. Activation of the phosphonate moiety with dimethylchloromethyleneammonium chloride, generated by reaction of thionyl chloride or triphosgene with dimethylformamide, proved to be the method of choice. The esters were also prepared by alkylation of the phosphonate group with dimethylformamide dialkyl acetals or a mixture of the appropriate alcohol with dimethylformamide dineopentylacetal.

引用

页码：1853 / 1869

页数：17

共 31 条

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