INSTANTANEOUS PREPARATION OF RADIOLABELED 5-IODO-2'-DEOXYURIDINE

被引：23

作者：

FOULON, CF ^{[1
]}

ZHANG, YZ ^{[1
]}

ADELSTEIN, SJ ^{[1
]}

KASSIS, AI ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115

来源：

APPLIED RADIATION AND ISOTOPES | 1995年 / 46卷 / 10期

关键词：

D O I：

10.1016/0969-8043(95)00214-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The fastest and most reliable preparation of radiolabeled 5-iodo-2'-deoxyuridine ([I-123/125/131]IUdR) is accomplished by iododemetallation. We describe a series of improvements to a previously published synthesis of radiolabeled IUdR by demercuration whereby [I-123/125/131]IUdR is synthesized instantly following the incubation of an aqueous solution of the chloromercury precursor with (NaI)-I-123/125/131 in the presence of Iodogen. The total procedure is completed in 5 min and does not require purification. Mercury content is low and HPLC indicates the total transformation of iodide into IUdR with no detectable UV-absorbing by-products.

引用

页码：1039 / 1046

页数：8

共 22 条

[1] THE ELECTROPHILIC IODINATION WITH I-131 OF N1-SUBSTITUTED URACILS USING CHLORAMINE-T AS OXIDANT [J].