EFFECT OF 6-OHDA LESIONS ON STRIATAL MESSENGER-RNA LEVELS ENCODING FOR GLUTAMATE-RECEPTOR SUBUNITS

被引：33

作者：

TREMBLAY, M

SALIN, P

SOGHOMONIAN, JJ

机构：

[1] HOP ENFANTS JESUS,CTR RECH NEUROBIOL,QUEBEC CITY,PQ G1J 1Z4,CANADA

[2] CNRS,NEUROBIOL CELLULAIRE & FUNCT LAB,MARSEILLE,FRANCE

来源：

NEUROREPORT | 1995年 / 6卷 / 16期

关键词：

GLUTAMATE RECEPTORS; AMPA; NMDA; STRIATUM; IN SITU HYBRIDIZATION; 6-HYDROXYDOPAMINE; MESSENGER-RNA;

D O I：

10.1097/00001756-199511000-00030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LEVELS of mRNAs encoding for subunits of glutamate receptors were measured by in situ hybridization in the rat striatum after unilateral injections of 6-hydroxydopamine in the substantia nigra. When compared with the contralateral striatum, levels of NMDAR1, GluR1 and GluR2 mRNAs were significantly higher in the dopamine-deafferented striatum. Comparison with saline-injected rats showed that the NMDAR1 and the GluR1 mRNA labelling was increased in the striatum ipsilateral to the lesion. In contrast, GluR2 mRNA labelling in 6-OHDA-injected rats was not different from that in saline-injected rats. These results support the hypothesis that experimental dopamine deafferentation induces functional changes at the level of glutamatergic synapses in the striatum.

引用

页码：2225 / 2229

页数：5

共 17 条

[1] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].