SYNTHESIS OF 6,7-BENZOMORPHAN AND RELATED NONQUATERNARY CARBON STRUCTURES WITH MARKED ANALGETIC ACTIVITY

被引：51

作者：

KANEMATSU, K

TAKEDA, M

JACOBSON, AE

MAY, EL

机构：

[1] Laboratory of Chemistry, National Institutes of Health, Bethesda

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6,7-Benzomorphan (9) has been synthesized from pyridine or 4-phenylpyridine. This compound (9), without a quaternary carbon or tertiary nitrogen, is codeine-like in analgetic activity as determined in the mouse hot-plate method. 2-Methyl-6,7-benzomorphan (8) and its 2′-hydroxy analog (15) are as active as their 5-methyl (quaternary carbon containing) relatives. © 1969, American Chemical Society. All rights reserved.

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页码：405 / +

页数：1

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