1,5-BENZODIAZOCINES

被引:33
作者
DERIEG, ME
SCHWEINI.RM
FRYER, RI
机构
[1] Chemical Research Department, Hoffmann-La Roche Inc., Nutley
关键词
D O I
10.1021/jo00838a039
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The syntheses of 2-(3-aminopropylamino)-5-chlorobenzophenones 2 and 9 and their intramolecular dehydrations to give 8-chloro-1,2,3,4-tetrahydro-6-phenyl-1,5-benzodiazocines 3 and 10 were effected. A procedure purported to yield a 8-chloro-3,4-dihydro-1,5-benzodiazocin-2-one has been found in fact to give a dimer. This procedure has been successfully utilized in the synthesis of 8-chloro-3,4-dihydro-1-methyl-6-phenyl-1,5-benzodiazocin-2(1H)-one 19, which has been structurally related to 10. A rationale for the anomalous results of this reaction is offered. © 1969, American Chemical Society. All rights reserved.
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页码:179 / &
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