STUDY OF THE ROTATIONAL DIFFUSION PROPERTIES OF PEPTIDES IN SOLUTION

In this paper we examine the theory and method for obtaining rotational diffusion coefficients for peptides in dilute solution from 13C‐nmr spin‐lattice relaxation data. We show that even for the case of nearly equal observed relaxation times of chemically and magnetically nonequivalent alpha‐carbons marked rotational anisotropy will be the usual case. We describe two interactive, minicomputer programs which are of general use in this type of work. The implications of this study on spectral density‐based conformational determinations of peptides is discussed. Copyright © 1979 John Wiley & Sons, Inc.