FUTURE-PROSPECTS FOR THE CHEMOTHERAPY OF HUMAN TRYPANOSOMIASIS .1. NOVEL APPROACHES TO THE CHEMOTHERAPY OF TRYPANOSOMIASIS

被引：36

作者：

FAIRLAMB, AH

机构：

[1] Parasite and Vector Biochemistry Unit, Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, Keppel Street

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0035-9203(90)90124-W

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Chemotherapy of trypanosomiasis and leishmaniasis is far from satisfactory and the discovery of new drugs has been slow. Emphasis on the empirical approach to drug development is now shifting towards a more rational, directed approach, which employs the modern tools of science. This is illustrated with respect to the newly discovered drug target, trypanothione, a unique metabolite which is critical for survival of Trypanosoma and Leishmania and absent from the host. © 1990, Royal Society of Tropical Medicine and Hygiene. All Rights Reserved.

引用

页码：613 / 617

页数：5

共 54 条

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