SALICYLATE TREATMENT OF EPIDEMIC KAWASAKI DISEASE IN NEW-YORK-CITY

被引：23

作者：

JACOBS, JC

机构：

[1] Department of Pediatries (Section of Rheumatology), Columbia University College of Physicians and Surgeons

[2] Babies Hospital and the Edward Daniels Faulkner Arthritis Clinic, Columbia-Presbyterian Medical Center, New York, NY

来源：

THERAPEUTIC DRUG MONITORING | 1979年 / 1卷 / 01期

关键词：

Kawasaki disease; Mucocutaneous lymph node syndrome; Salicylate treatment; Serum levels;

D O I：

10.1097/00007691-197901000-00013

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Kawasaki disease, mucocutaneous lymph node syndrome, thought to be rare in the continental United States, occurred in epidemic form in New York City and adjacent New York and New Jersey in November-December, 1977. Aspirin and corticosteroids, reported to be ineffective treatment, were found to completely control the illness in affected children, provided adequate doses to achieve therapeutic blood levels were administered. Patients were found to malabsorb aspirin (and perhaps also to destroy it) and so required extraordinarily high doses during the acute phase; during recovery, doses had to be lowered to the usual range to avoid toxicity. The need for hospitalization and morbidity were reduced and, hopefully, mortality will also be reduced. The importance of not judging a drug ineffective in a disease without demonstrating adequate serum levels was again shown. © 1979 Raven Press, New York.

引用

页码：123 / 130

页数：8

共 19 条

[1]

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[2]

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[3]

Kawasaki T., Kosaki F., Okawa S., Shigematsu I., Yanagawa H., A new infantile acute febrile mucocutaneous lymph node syndrome prevailing in Japan, Pediatrics, 54, pp. 271-281, (1974)

[4]

Kawasaki Disease It's Official and It's Here, Med World News, 18, Dec 12, pp. 57-69, (1977)

[5]

A look at mucocutaneous lymph node syndrome, Consultant, 18, Mar, pp. 60-61, (1978)

[6]

Fetterman G.H., Hashida Y., Mucocutaneous lymph node syndrome: A disease widespread in Japan which demands our attention, Pediatrics, 54, pp. 268-270, (1974)

[7]

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[8]

Glanz S., Bittner S.J., Berman M.A., Dolan T.F., Talner N.S., Regression of coronary-artery aneurysms in infantile polyarteritis nodosa, N Engl J Med, 294, pp. 939-941, (1976)

[9]

Fujiwara H., Hamashima Y., Pathology of the heart in Kawasaki disease, Pediatrics, 61, pp. 100-107, (1978)

[10]

Jacobs J.C., Pesce M., Micromeasurement of plasma salicylate in arthritic children, Arthritis Rheum, 21, pp. 129-132, (1978)

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