DNA-BINDING PROTEIN RAP1 STIMULATES MEIOTIC RECOMBINATION AT THE HIS4 LOCUS IN YEAST

被引：94

作者：

WHITE, MA

WIERDL, M

DETLOFF, P

PETES, TD

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 21期

关键词：

SACCHAROMYCES-CEREVISIAE; RECOMBINATION HOTSPOT; GENE CONVERSION;

D O I：

10.1073/pnas.88.21.9755

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the yeast Saccharomyces cerevisiae, as in other eukaryotes, some regions of the genome have a much higher rate of meiotic recombination than others. We show below that the binding of the RAP1 protein to a site upstream of the HIS4 gene is necessary for a high rate of meiotic (but not mitotic) recombination at this locus. A mutation in the RAP1 binding site at HIS4 results in a decrease in recombination; overproduction of RAP1 causes an increase in recombination at HIS4 above wild-type levels.

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页码：9755 / 9759

页数：5

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