SURFACE MODIFICATION OF A BIOCOMPATIBLE POLYMER BASED ON POLYURETHANE FOR ARTIFICIAL BLOOD-VESSELS

被引：25

作者：

ANDERHEIDEN, D

KLEE, D

HOCKER, H

HELLER, B

KIRKPATRICK, CJ

MITTERMAYER, C

机构：

[1] Department of Macromolecular and Textile Chemistry, RWTH Aachen, Aachen, 5100

[2] Institute of Pathology, Medical Faculty RWTH Aachen, Aachen, 5100

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 1992年 / 3卷 / 01期

关键词：

D O I：

10.1007/BF00702936

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An OH-functionalized poly(carbonate urethane) (PCU) is used for developing a new antithrombogenic surface. Biomolecules like glycine or the fibronectin fragment Gly-Arg-Gly-Asp-Ser (GRGDS) are covalently bound to the PCU surface by succinyl dichloride coupling. The modification steps are controlled by infrared spectroscopy and amino acid analysis. Successfully modified films are tested under stationary cell culture conditions.

引用

页码：1 / 4

页数：4

共 8 条

[1]

Buss H., Blut- und Lymphgefäße, (1984)

[2]

Klee D., Mittermayer C., Hocker H., Plastverarbeiter, 38, 4, (1987)

[3]

Tittmann F.R., Beach W.F., Parylene coated polypropylene microfibres as cell seeding substrates, Synthetic biomedical polymers, concepts and applications, (1980)

[4]

Mansfield P.B., Wechezak A.R., Sauvage L.R., Preventing thrombus on artificial vascular surfaces. True endothelial cell linings, Trans. Amer. Soc. Artif. Int. Organs, 21, pp. 264-272, (1975)

[5]

Breuers W., Klee D., Mittermayer C., Hocker H., J. Mater. Sci. Mater. Med., 2, (1991)

[6]

Anderheiden D., Brenner O., Klee D., Kaufmann R., Richter H., Mittermayer C., Hocker H., Angewandte Makromolekulare Chemie, 185-186, (1991)

[7]

Khorana H.G., Chem. Rev., 53, (1953)

[8]

Carraway K.L., Koshland D.E., Meth. Enzymol., 25 B, (1972)

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