CARBAMAZEPINE-INDUCED NEUROTOXICITY AND ITS PREVENTION BY NMDA IN CULTURED CEREBELLAR GRANULE CELLS

被引：21

作者：

GAO, XM ^{[1
]}

CHUANG, DM ^{[1
]}

机构：

[1] NIMH,BIOL PSYCHIAT BRANCH,BLDG 10,ROOM 3N212,9000 ROCKVILLE PIKE,BETHESDA,MD 20892

来源：

NEUROSCIENCE LETTERS | 1992年 / 135卷 / 02期

关键词：

CARBAMAZEPINE; NEUROTOXICITY; NMDA; CEREBELLAR GRANULE CELL; VERATRIDINE; LITHIUM; COLCHICINE;

D O I：

10.1016/0304-3940(92)90426-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Long-term neurotoxicity of carbamazepine was studied in cultured cerebellar granule cells. Treatment of cells with carbamazepine for 3 days induced a dose-dependent neurotoxicity detected by a loss of [H-3]ouabain binding to Na+,K+-ATPase, and [H-3]N-methyl scopolamine binding to muscarinic cholinergic receptors as well as by direct morphologic examination. NMDA protected against carbamazepine-induced toxicity and this protection was blocked by 2-amino-5-phosphono-valerate (APV). The neurotoxicity induced by carbamazepine may be involved in the teratogenic and adverse effects of overdose associated with the treatment of manic-depressive illness and seizures.

引用

页码：159 / 162

页数：4

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