MODULATION OF SPLENIC MACROPHAGES, AND SWINE LEUKOCYTE ANTIGEN (SLA) AND VIRAL-ANTIGEN EXPRESSION FOLLOWING AFRICAN SWINE FEVER VIRUS (ASFV) INOCULATION

被引:20
作者
GONZALEZJUARRERO, M
LUNNEY, JK
SANCHEZVIZCAINO, JM
MEBUS, C
机构
[1] USDA ARS, BELTSVILLE AGR RES CTR, LPSI, HELMINTH DIS LAB B1040, BELTSVILLE, MD 20705 USA
[2] USDA ARS, PLUM ISL ANIM DIS CTR, FOREIGN ANIM DIS DIAGNOST LAB, APHIS, GREENPORT, NY 11944 USA
[3] INST NACL INVEST AGR, DEPT VIROL ANIM, MADRID, SPAIN
关键词
D O I
10.1007/BF01317145
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Expression of viral and major histocompatibility complex (MHC) antigens and localization of T cells and macrophages was studied in frozen tissue sections of spleens taken from normal pigs or from pigs inoculated with highly virulent Lisbon 60 (L60), or with moderately virulent Dominican Republic 1978 (DR-II), African swine fever virus (ASFV) isolates. Splenic sections from L60 inoculated pigs exhibited a large decrease in macrophage staining, whereas DR-II infected animals appeared more intensely stained in the macrophage sheath arteries. Class I and class II MHC expression was decreased in spleens from pigs infected with either isolate at 3 day post inoculation (DPI). This was reversed in DR-II inoculated pigs at 4 DPI. Splenic tissue sections from L60 inoculated pigs exhibited only a marginal increase in SLA expression at a later time, 6 DPI. We suggest that the recovery of SLA expression during infection of pigs with ASFV is associated with survival or replacement of macrophages in the spleen leading to an effective immune response against the virus.
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页码:145 / 156
页数:12
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