KINETIC ASPECTS OF CONTROL OF PLASMID REPLICATION BY ANTISENSE RNA

被引：72

作者：

NORDSTROM, K

WAGNER, EGH

机构：

[1] K. Nordström and E.G.H. Wagner are, the Department of Microbiology, The Biomedical Center, S-751 23 Uppsala

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 07期

关键词：

D O I：

10.1016/0968-0004(94)90008-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasmids are replicating DNA molecules that are present in defined numbers of copies per cell. They encode systems that control their replication such that given steady-state values for their copy numbers are maintained. This is a special type of control, since it requires the genome to measure its concentration continuously and adjust its rate of replication to parallel the rate of growth of the cell mass. In this review we discuss the quantitative kinetic properties of copy-number control of the R1 plasmid, in which the control device is an antisense RNA that controls the synthesis of a protein that is rate-limiting for replication of the plasmid.

引用

页码：294 / 300

页数：7

共 21 条

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