Nuclear organization of pre-mRNA processing

被引：107

作者：

Spector, David L. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 03期

关键词：

D O I：

10.1016/0955-0674(93)90009-F

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have suggested that small nuclear ribonucleoprotein particles (snRNPs), non-snRNP splicing factors, and several heterogeneous nuclear RNP proteins change their organization within the cell in response to transcriptional activity. Several of the RNA substrates with which these factors interact have been shown to localize in tracks that are associated with regions in which splicing factors are concentrated (nuclear speckles). It is now thought that pre-mRNA splicing may occur within these tracks.

引用

页码：442 / 447

页数：6

共 75 条

[1] INDEPENDENT DEPOSITION OF HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS AND SMALL NUCLEAR RIBONUCLEOPROTEIN-PARTICLES AT SITES OF TRANSCRIPTION [J].

AMERO, SA ;

RAYCHAUDHURI, G ;

CASS, CL ;

VANVENROOIJ, WJ ;

HABETS, WJ ;

KRAINER, AR ;

BEYER, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8409-8413

[2] HUMAN AUTOANTIBODY TO A NOVEL PROTEIN OF THE NUCLEAR COILED BODY - IMMUNOLOGICAL CHARACTERIZATION AND CDNA CLONING OF P80-COILIN [J].

ANDRADE, LEC ;

CHAN, EKL ;

RASKA, I ;

PEEBLES, CL ;

ROOS, G ;

TAN, EM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (06) :1407-1419

[3] ULTRASTRUCTURAL ORGANIZATION AND BIOCHEMICAL CHARACTERIZATION OF CHROMATIN-RNA-PROTEIN COMPLEXES ISOLATED FROM MAMMALIAN-CELL NUCLEI [J].

BACHELLERIE, JP ;

PUVION, E ;

ZALTA, JP .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1975, 58 (02) :327-337

[4] LOCALIZATION OF AN ACETYLCHOLINE-RECEPTOR INTRON TO THE NUCLEAR-MEMBRANE [J].

BERMAN, SA ;

BURSZTAJN, S ;

BOWEN, B ;

GILBERT, W .

SCIENCE, 1990, 247 (4939) :212-214

[5] SPLICE SITE SELECTION, RATE OF SPLICING, AND ALTERNATIVE SPLICING ON NASCENT TRANSCRIPTS [J].

BEYER, AL ;

OSHEIM, YN .

GENES & DEVELOPMENT, 1988, 2 (06) :754-765

[6] GENE GATING - A HYPOTHESIS [J].

BLOBEL, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8527-8529

[7] NUCLEAR-BODIES (NBS) - A NEWLY REDISCOVERED ORGANELLE [J].

BRASCH, K ;

OCHS, RL .

EXPERIMENTAL CELL RESEARCH, 1992, 202 (02) :211-223

[8] INVIVO DETECTION OF SNRNP-RICH ORGANELLES IN THE NUCLEI OF MAMMALIAN-CELLS [J].

CARMOFONSECA, M ;

PEPPERKOK, R ;

SPROAT, BS ;

ANSORGE, W ;

SWANSON, MS ;

LAMOND, AI .

EMBO JOURNAL, 1991, 10 (07) :1863-1873

[9] MAMMALIAN NUCLEI CONTAIN FOCI WHICH ARE HIGHLY ENRICHED IN COMPONENTS OF THE PRE-MESSENGER-RNA SPLICING MACHINERY [J].

CARMOFONSECA, M ;

TOLLERVEY, D ;

PEPPERKOK, R ;

BARABINO, SML ;

MERDES, A ;

BRUNNER, C ;

ZAMORE, PD ;

GREEN, MR ;

HURT, E ;

LAMOND, AI .

EMBO JOURNAL, 1991, 10 (01) :195-206

[10] TRANSCRIPTION-DEPENDENT COLOCALIZATION OF THE U1, U2, U4/U6, AND U5 SNRNPS IN COILED BODIES [J].

CARMOFONSECA, M ;

PEPPERKOK, R ;

CARVALHO, MT ;

LAMOND, AI .

JOURNAL OF CELL BIOLOGY, 1992, 117 (01) :1-14

← 1 2 3 4 5 6 7 8 →