DECREASED STRIATAL D2-DOPAMINE RECEPTORS IN OBESE ZUCKER RATS - CHANGES DURING AGING

被引：51

作者：

HAMDI, A

PORTER, J

PRASAD, C

机构：

[1] PENNINGTON BIOMED RES CTR, NEUROSCI LAB, BATON ROUGE, LA 70808 USA

[2] LOUISIANA STATE UNIV, MED CTR, DEPT MED ENDOCRINOL, NEW ORLEANS, LA 70112 USA

[3] LOUISIANA STATE UNIV, MED CTR, DEPT PHYSIOL, OBES RES PROGRAM, NEW ORLEANS, LA 70112 USA

来源：

BRAIN RESEARCH | 1992年 / 589卷 / 02期

基金：

美国国家卫生研究院;

关键词：

AGING; D2-DOPAMINE RECEPTOR; HYPERPHAGIA; OBESITY; STRIATUM; ZUCKER RAT;

D O I：

10.1016/0006-8993(92)91296-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The specific binding of [H-3]YM-09151-2 was used to investigate the possible differences in age-associated changes in striatal D2 dopamine (DA) receptor properties in genetically obese (fa/fa) Zucker rats and their lean (Fa/?) littermates. The maximal binding sites (B(max)) of D2 DA receptors was found to decline with age in both obese and lean rats; the rate of decline in receptor B(max) was slightly higher in lean than obese rats. However, the B(max) of D2 DA receptor in 6-, 12- and 18-month-old obese rats was significantly lower compared to the age-matched lean rats. These data indicate that obesity decreases the number of striatal D2 DA receptors without affecting the rate at which receptor number decreases with age.

引用

页码：338 / 340

页数：3

共 12 条

[1] ANTIBODIES AGAINST SYNTHETIC PEPTIDES PREDICTED FROM THE NUCLEOTIDE-SEQUENCE OF D2 RECEPTOR RECOGNIZE NATIVE DOPAMINE RECEPTOR PROTEIN IN RAT STRIATUM [J].