ISOLATION OF GLUTATHIONE-DEFICIENT MUTANTS OF THE YEAST SACCHAROMYCES-CEREVISIAE

被引:51
作者
KISTLER, M [1 ]
SUMMER, KH [1 ]
ECKARDT, F [1 ]
机构
[1] GESELL STRAHLEN & UMWELTFORSCH MBH, TOXIKOL ABT, D-8042 NEUHERBERG, GERMANY
来源
MUTATION RESEARCH | 1986年 / 173卷 / 02期
关键词
D O I
10.1016/0165-7992(86)90087-4
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Glutathione-deficient (gsh-) mutants of the yeast Saccharomyces cerevisiae were isolated after UV treatment using MNNG as selective agent. For genetic and biochemical characterization 5 mutant strains were chosen which exhibited considerably decreased residual GSH contents varying from 2 to 6% of the wild-type levels. All 5 isolates showed a 2:2 segregation of the gsh-:GSH+ phenotypes alluding to a monogenic recessive mutation. Complementation analysis indicates that all gsh- mutants belong to one complementation group.
引用
收藏
页码:117 / 120
页数:4
相关论文
共 18 条
[1]   MAPPING OF GSHA, A GENE FOR BIOSYNTHESIS OF GLUTATHIONE IN ESCHERICHIA-COLI K12 [J].
APONTOWEIL, P ;
BERENDS, W .
MOLECULAR & GENERAL GENETICS, 1975, 141 (02) :91-95
[2]   ISOLATION AND INITIAL CHARACTERIZATION OF GLUTATHIONE-DEFICIENT MUTANTS OF ESCHERICHIA-COLI K-12 [J].
APONTOWEIL, P ;
BERENDS, W .
BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 399 (01) :10-22
[3]  
BOYLAND E, 1969, ADV ENZYMOL RAMB, V32, P173
[4]   ISOLATION OF AN ESCHERICHIA-COLI MUTANT DEFICIENT IN GLUTATHIONE SYNTHESIS [J].
FUCHS, JA ;
WARNER, HR .
JOURNAL OF BACTERIOLOGY, 1975, 124 (01) :140-148
[5]  
HABIG WH, 1974, J BIOL CHEM, V249, P7130
[6]   ISOLATION OF A MUTANT OF SALMONELLA-TYPHIMURIUM STRAIN TA1535 WITH DECREASED LEVELS OF GLUTATHIONE (GSH-) - PRIMARY CHARACTERIZATION AND CHEMICAL MUTAGENESIS STUDIES [J].
KERKLAAN, P ;
BOUTER, S ;
MOHN, G .
MUTATION RESEARCH, 1983, 122 (3-4) :257-266
[7]   THE ROLE OF NON-ENZYMATIC REACTIONS OF GLUTATHIONE IN XENOBIOTIC METABOLISM [J].
KETTERER, B .
DRUG METABOLISM REVIEWS, 1982, 13 (01) :161-187
[9]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[10]   SELECTIVE MODIFICATION OF GLUTATHIONE METABOLISM [J].
MEISTER, A .
SCIENCE, 1983, 220 (4596) :472-477