INVITRO STUDY OF SEVERAL IONOPHORE ANTIBIOTICS AND SOME OF THEIR DERIVATIVES .2. CHARACTERIZATION OF THE IONOPHORE PROPERTIES OF THE COMPOUNDS IN A MODEL SYSTEM FOR NA+ AND K+ IONS

被引：6

作者：

CAFFARELMENDEZ, S ^{[1
]}

DEMUYNCK, C ^{[1
]}

JEMINET, G ^{[1
]}

机构：

[1] UNIV CLERMONT FERRAND 2, UFR RECH SCI & TECH,CHIM ORGAN BIOL LAB,CNRS, UA 485, BP 45, F-63170 AUBIERE, FRANCE

来源：

REPRODUCTION NUTRITION DEVELOPMENT | 1987年 / 27卷 / 05期

关键词：

D O I：

10.1051/rnd:19870704

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transport of Na+ and K+ by different carboxylic polyether antibiotics and some of their derivatives was measured in a triphasic water/chloroform/water model system. Monensin, nigericin, narasin and lasalocid proved to be efficient K+ carriers, while grisorixin, alborixin and X 14547A gave lower ionic fluxes. Furthermore, the structural modifications of nigericin, grisorixin and lasalocid reduced the ionophore properties of the corresponding natural metabolite. Monensin was also characterized as a good Na+ carrier. Cation transport results were in keeping with those of a previous study on the endproducts of rumen fermentation. In both cases monensin, nigericin narasin, and lasalocid were the most efficient compounds.

引用

页码：921 / 928

页数：8

共 16 条

[1] TRANSPORT OF POTASSIUM-IONS ACROSS PLANAR LIPID-MEMBRANES BY THE ANTIBIOTIC, GRISORIXIN .1. THE EQUILIBRIUM STATE AND SELF-DIFFUSION K+ FLUXES [J].

AMBLARD, G ;

SANDEAUX, R ;

SANDEAUX, J ;

GAVACH, C .

JOURNAL OF MEMBRANE BIOLOGY, 1985, 88 (01) :15-23

[2] THERMODYNAMIC CONSIDERATION OF ION TRANSPORTING ANTIBIOTICS [J].

ASHTON, R ;

STEINRAUF, LK .

JOURNAL OF MOLECULAR BIOLOGY, 1970, 49 (03) :547-+

[3]

Bakker E. P., 1979, ANTIBIOTICS, V5, P67

[4] IONOPHORES - THEIR EFFECT ON PRODUCTION EFFICIENCY AND MODE OF ACTION [J].

BERGEN, WG ;

BATES, DB .

JOURNAL OF ANIMAL SCIENCE, 1984, 58 (06) :1465-1483

[5]

BOLTE J, 1986, B SOC CHIM FR, P370

[6] COMPARATIVE STUDIES OF 3 IONOPHORE ANTIBIOTICS - X.537A (LASALOCIDE), A.23187 (CALCIMYCIDE) AND X.14547A - COMPLEXATION OF IA AND IIA CATIONS AND CA++ TRANSPORT [J].

BOLTE, J ;

DEMUYNCK, C ;

JEMINET, G ;

JUILLARD, J ;

TISSIER, C .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1982, 60 (08) :981-989

[7]

BOLTE J, 1983, PHYSICAL CHEM TRANSM, P247

[8] INVITRO STUDY OF SEVERAL IONOPHORE ANTIBIOTICS AND SOME OF THEIR DERIVATIVES .1. ACTION ON FERMENTATION PRODUCTS IN THE RUMEN [J].

CAFFARELMENDEZ, S ;

JOUANY, JP ;

DEMUYNCK, C .

REPRODUCTION NUTRITION DEVELOPMENT, 1986, 26 (06) :1295-1303

[9]

DELORT AM, UNPUB

[10] MANIPULATION OF RUMEN METABOLISM WITH ADDITIVES [J].

DURAND, M .

ANNALES DE ZOOTECHNIE, 1982, 31 (01) :47-76

← 1 2 →