SINGLE-DOSE DETERMINATION OF SUPPOSITORIES CONTAINING PHENYLEPHRINE, LIDOCAINE AND BETAMETHASONE VALERATE BY REVERSED-PHASE ION-PAIR LIQUID-CHROMATOGRAPHY

被引:10
作者
HELBOE, P
THOMSEN, M
机构
关键词
D O I
10.1016/0378-5173(79)90038-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The power of reversed-phase ion-pair liquid chromatography in drug analysis is demonstrated by the development of a method for the separation and quantitative determination of phenylephrine, lidocaine, and betamethasone valerate in combination. The separation is achieved on Nucleosil 5 C8 as the stationary phase and with methanol-0.01 M sodium dihydrogenphosphate (7:3) containing 0.005 M sodium dodecane sulphonate as the mobile phase. The method allows fast and reliable analysis of the three drug substances, and it is used for single-dose determination of a suppository preparation. © 1979.
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页码:317 / 324
页数:8
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