POTENTIAL ANTI-TUMOR AGENTS .11. INVESTIGATION OF THE ANTI-TUMOR ACTIVITY OF MICROMELUM-INTEGERRIMUM (RUTACEAE)

被引：56

作者：

CASSADY, JM

OJIMA, N

CHANG, CJ

MCLAUGHLIN, JL

机构：

[1] Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacol Sciences, Purdue University, Indiana, West Lafayette

来源：

JOURNAL OF NATURAL PRODUCTS | 1979年 / 42卷 / 03期

关键词：

D O I：

10.1021/np50003a005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extracts of Micromelum integerrimum (Buch.-Ham. ex Coleb.) M. Roem. were fractionated based on in vivo activity in mice in the P-388 lymphocytic leukemia system. Activity in ethanol extracts was concentrated in the chloroform partition fraction, which was further resolved by chromatography on silica gel. The known coumarins, micromelin and scopoletin, were crystallized from the active fractions and demonstrated to have antitumor activities. Micromelin was converted to the corresponding butenolide (deoxymicromelin) which was inactive in the 9KB assay. © 1979, American Chemical Society. All rights reserved.

引用

页码：274 / 278

页数：5

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