DELAYED NEUROTOXICITY OF INTRAVENTRICULAR INTERLEUKIN-2 - A CASE-REPORT

被引：22

作者：

MEYERS, CA

YUNG, WKA

机构：

[1] Department of Neuro-Oncology, The University of Texas, Anderson Cancer Center, Houston, TX

来源：

JOURNAL OF NEURO-ONCOLOGY | 1993年 / 15卷 / 03期

关键词：

NEUROTOXICITY; INTERLEUKIN-2; NEUROPSYCHOLOGICAL TESTING;

D O I：

10.1007/BF01050073

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction. This deterioration started 3 months post-treatment and worsened over the ensuing 4 years. MRI revealed white matter abnormalities that were not present on the pretreatment scan. Although free of disease, the patient has a subcortical dementia and is unable to work. The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.

引用

页码：265 / 267

页数：3

共 7 条

[1] TRANSIENT FOCAL NEUROLOGIC DEFICITS COMPLICATING INTERLEUKIN-2 THERAPY [J].