THE FREE-ENERGY CHANGE OF RESTRICTING A BOND ROTATION IN THE BINDING OF PEPTIDE ANALOGS TO VANCOMYCIN GROUP ANTIBIOTICS

被引：24

作者：

GERHARD, U ^{[1
]}

SEARLE, MS ^{[1
]}

WILLIAMS, DH ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CAMBRIDGE CTR MOLEC RECOGNIT,CHEM LAB,LENSFIELD RD,CAMBRIDGE CB2 1EW,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80670-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The adverse cost in free energy of restricting an internal bond rotation in the binding of the peptide ligands N-succinyl-D-alanine and N-fumaryl-D-alanine to the antibiotic Ristocetin A, has been estimated to be 3.7+/-0.9 kJ mol-1 per rotor by comparison of the difference in free energies of binding measured by UV spectrometry.

引用

页码：803 / 808

页数：6

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