DIFFERENTIAL SENSITIVITY OF HEPATITIS-C VIRUS QUASI-SPECIES TO INTERFERON-A THERAPY

被引:27
作者
MIZOKAMI, M
LAU, JYN
SUZUKI, K
NAKANO, T
GOJOBORI, T
机构
[1] UNIV FLORIDA,DEPT MED,HEPATOBILIARY DIS SECT,GAINESVILLE,FL 32610
[2] NAGOYA CITY UNIV,DEPT MED 2,NAGOYA,AICHI,JAPAN
[3] NATL INST GENET,DNA RES CTR,MISHIMA,SHIZUOKA 411,JAPAN
关键词
HEPATITIS C VIRUS; INTERFERON-ALPHA; MOLECULAR EVOLUTIONARY ANALYSIS; QUASI-SPECIES; SELECTION;
D O I
10.1016/S0168-8278(94)80254-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-alpha therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-alpha therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-alpha therapy. However, only group 3 remained after interferon-alpha therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-alpha. (C) Journal of Hepatology.
引用
收藏
页码:884 / 886
页数:3
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