INFLUENCE OF PYROPHOSPHATE ON TRANSFORMATION OF AMORPHOUS TO CRYSTALLINE CALCIUM PHOSPHATE

被引：130

作者：

FLEISCH, H

RUSSELL, RGG

BISAZ, S

TERMINE, JD

POSNER, AS

机构：

[1] Department of Pathophysiology, University of Berne

[2] Department of Biochemistry, The Hospital for Special Surgery, New York, N.Y.

来源：

CALCIFIED TISSUE RESEARCH | 1968年 / 2卷 / 01期

关键词：

Calcium Phosphate; Crystallization; Phosphatase; Pyrophosphatase; Pyrophosphate;

D O I：

10.1007/BF02279193

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The transformation of amorphous calcium phosphate into its crystalline form has been studied in vitro under various conditions. The transformation was followed by changes in the pH and in the calcium and phosphate content of the solution and by changes in the Ca/P ratio and x-ray diffraction patterns of the solid phase. It was found that inorganic pyrophosphate markedly increased the time required for the transformation under the various conditions used. The addition of intestinal alkaline phosphatase abolished this retarding effect of pyrophosphate on the transformation. It is proposed that pyrophosphate may be one of the factors that allows part of the bone mineral to persist in a non-crystalline state. The alkaline phosphatase of bone, by virtue of its pyrophosphatase activity, might be able to accelerate the transformation process in vivo. © 1968 Springer-Verlag.

引用

页码：49 / +

页数：1

共 29 条

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