BIOTRANSFORMATION OF HETACILLIN TO AMPICILLIN IN MAN

被引：6

作者：

BROWN, DM

HANNAN, DP

LANGLEY, PF

机构：

[1] Medicinal Research Department, Beecham Research Laboratories, Betchworth, Surrey England, Brockham Park

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1969年 / 15卷 / 01期

关键词：

D O I：

10.1016/0041-008X(69)90141-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A high voltage electrophoresis technique has been used to assay directly a mixture of two penicillins, ampicillin and hetacillin, in the plasma of humans after oral administration of hetacillin. Results show that ampicillin accounts for over 90% of the total biological activity at the peak plasma concentration, and it may be concluded that the clinical effectiveness of hetacillin is due to its conversion to ampicillin. © 1969.

引用

页码：136 / &