PHOTOMETRIC ACID-BASE TITRATIONS IN THE PRESENCE OF AN IMMISCIBLE SOLVENT

被引：36

作者：

CANTWELL, FF

MOHAMMED, HY

机构：

[1] Department of Chemistry, University of Alberta, Edmonton, Alberta

来源：

ANALYTICAL CHEMISTRY | 1979年 / 51卷 / 02期

关键词：

D O I：

10.1021/ac50038a016

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An apparatus is described which permits continuous monitoring of the UV absorbance of one phase in a vigorously agitated mixture of an aqueous and a water-immiscible organic solvent. Photometric titrations, using sodium hydroxide titrant, are performed in such a two-phase system on weak acid drug substances which show no spectral change upon deprotonation. Theoretical titration equations are derived and verified experimentally by titrating dextromethorphan hydrobromide. Four amine hydrohalide drugs are titrated by the new technique at concentrations between 8X10-4 M and 3X10-3 M with precision and accuracy of 1-2 ppt. © 1979, American Chemical Society. All rights reserved.

引用

页码：218 / 223

页数：6

共 11 条

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