G0 IS A MAJOR GROWTH CONE PROTEIN SUBJECT TO REGULATION BY GAP-43

被引：418

作者：

STRITTMATTER, SM

VALENZUELA, D

KENNEDY, TE

NEER, EJ

FISHMAN, MC

机构：

[1] MASSACHUSETTS GEN HOSP, DEV BIOL LAB, BOSTON, MA 02114 USA

[2] HARVARD UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT NEUROL, BOSTON, MA 02115 USA

[3] HARVARD UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MED, BOSTON, MA 02115 USA

[4] COLUMBIA UNIV, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA

[5] BRIGHAM & WOMENS HOSP, DIV CARDIOVASC, BOSTON, MA 02115 USA

来源：

NATURE | 1990年 / 344卷 / 6269期

关键词：

D O I：

10.1038/344836a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-γ-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0in the growth cone may be regulated by intracellular as well as extracellular signals. © 1990 Nature Publishing Group.

引用

页码：836 / 841

页数：6

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