SYNTHESIS AND SULFATION OF BRANCHED DEXTRANS

被引：13

作者：

HATANAKA, K ^{[1
]}

HIROBE, T ^{[1
]}

YOSHIDA, T ^{[1
]}

YAMANAKA, M ^{[1
]}

UYRU, T ^{[1
]}

机构：

[1] UNIV TOKYO,INST IND SCI,ROPPONGI,MINATO KU,TOKYO 106,JAPAN

来源：

POLYMER JOURNAL | 1990年 / 22卷 / 05期

关键词：

Anhydrosugar; Branched polysaccharide; Dextran; Ring-opening polymerization; Sulfated Polysaccharide;

D O I：

10.1295/polymj.22.435

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

2, 4-Di-O-benzyl-(1→6)-α-d-glucopyranan, which was synthesized by ring-opening polymerization of 1, 6-anhydro-2, 4-di-O-benzyl-3-O-tert-butyldimethylsilyl-β-d-glucopy-ranose and subsequent desilylation, was β-glucosylated or α-mannosylated by the orthoester method. Deprotection of glycosylated polysaccharides with sodium in liquid ammonia was performed to give branched dextrans with free hydroxyl groups. Sulfation of the branched dextrans was carried out with piperidine N-sulfonic acid in dimethylsulfoxide to give new heparinoids. The Polymers were characterized by NMR spectroscopy, gel permeation chromatography, and optical rotation. © 1990 The Society of Polymer Science, Japan.

引用

页码：435 / 441

页数：7

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