PREPARATION AND CHARACTERIZATION OF LIPID VESICLES CONTAINING MAGNETITE AND AN ANTICANCER DRUG

被引:12
作者
ISHII, F [1 ]
TAKAMURA, A [1 ]
ISHIGAMI, Y [1 ]
机构
[1] NATL CHEM LAB IND,TSUKUBA,IBARAKI 305,JAPAN
关键词
D O I
10.1080/01932699008943284
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The preparation and physicochemical properties of lipid vesicles, containing magnetite (Fe3O4) and an anticancer agent (5-flurouracil) were described. The possibility of using the resulting lipid vesicles as a targeting carrier was examined both in vitro and in vivo. From measurements of viscosity, the observational data in this study were found to be in fairly good accord with the theoretically derived viscosity equation described by Brinkman or Oliver and Ward. The resulting lipid vesicles containing very fine Fe3O4 particles were found to act as rigid spheres in solution. At a field strength of 4000 G, more than 80% of the lipid vesicles infused were found to be retained in the target site of the ear vasculature in rabbits.
引用
收藏
页码:581 / 592
页数:12
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